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Pharmaceutical company Alphapharm has advised that Presolol 100 (labetalol hydrochloride 100 mg) tablets are in shortage until 3 October 2025 due to manufacturing issues. The alternative strength of Presolol 200 (labetalol hydrochloride 200 mg) tablets is available.
Labetalol is used to treat all grades of hypertension.
To help patients access this essential medicine, we have made a Serious Scarcity Substitution Instrument (SSSI) that starts on 26 August 2025 and allows a pharmacist to substitute the prescribed labetalol 100 mg with labetalol 200 mg, if appropriate, without a new prescription.
With the substitution, one tablet of Presolol 100 (labetalol 100 mg) is equivalent to half a tablet of Presolol 200 (labetalol 200 mg).
For detailed information about the shortage, the SSSI and important factors when considering a substitution, visit About the shortage of Presolol 100 (labetalol hydrochloride 100 mg) tablets.
For more information about SSSIs see Substituting scarce medicines and Serious Scarcity Substitution Instruments (SSSIs).