The 17 July 2002 issue of JAMA has the report of a large study of women using long-term oestrogen-only therapy in which an increase in incidence of cancer of the ovary was observed.
The increased risk translates to an additional 3 cases per 10 000 women after ten years of therapy. The risk increases further with longer therapy.
The study looked at long-term disease prevention and not short-term management of symptoms at the time of menopause. No increase in the risk of cancer of the ovary was seen in women using combination oestrogen and progestin therapy, but numbers studied were small for these women.
The Department of Health and Aged Care acknowledges First Nations peoples as the Traditional Owners of Country throughout Australia, and their continuing connection to land, sea and community. We pay our respects to them and their cultures, and to all Elders both past and present.