Safety review: Codeine use in children and ultra-rapid metabolisers

Version 1.0, October 2015

1 October 2015

The TGA has carried out a safety review into codeine use in children and rapid metabolisers.

The review concerned the safety of use of all codeine-containing products in children and breast-feeding mothers, in the context of genetically determined rapid metabolism of codeine to morphine.

The issue of codeine use in children has also been considered recently by the following:

As the final decision on the scheduling of codeine will impact on implementation of the recommendations contained in the TGA safety review, TGA will undertake consultation with stakeholders once the final scheduling decision is published.

Safety review

This review concerns the safety of use of all codeine-containing products in children and breast-feeding mothers, in the context of genetically determined ultra-rapid metabolism of codeine to morphine.

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